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Julie A DeMartino Selected Research

Hypoxia-Inducible Factor-Proline Dioxygenases

12/2016Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
4/20121,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

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Julie A DeMartino Research Topics

Disease

4Inflammation (Inflammations)
02/2013 - 06/2003
2Anemia
12/2016 - 04/2012
2Infections
01/2004 - 08/2002
1Lupus Nephritis
01/2022
1Hypoxia (Hypoxemia)
12/2016
1Fibrosis (Cirrhosis)
08/2013
1Rheumatoid Arthritis
02/2013
1HIV Infections (HIV Infection)
08/2007
1Virus Diseases (Viral Diseases)
01/2004
1Viremia
11/2003
1Hyperalgesia
06/2003
1Demyelinating Diseases (Demyelinating Disease)
06/2003
1Neuralgia (Stump Neuralgia)
06/2003
1Pain (Aches)
06/2003
1Chronic Pain
06/2003

Drug/Important Bio-Agent (IBA)

5Chemokine ReceptorsIBA
08/2007 - 06/2003
2Hypoxia-Inducible Factor-Proline DioxygenasesIBA
12/2016 - 04/2012
2Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
12/2016 - 04/2012
1Biomarkers (Surrogate Marker)IBA
01/2022
1Galectin 3 (LGALS3)IBA
01/2022
1Carrier Proteins (Binding Protein)IBA
01/2022
1bis(4- methoxyphenyl)methyl)- 4- hydroxy- 2- (pyridazin- 3- yl)pyrimidine- 5- carboxamideIBA
12/2016
1Bleomycin (Blenoxane)FDA LinkGeneric
08/2013
1Protein Isoforms (Isoforms)IBA
08/2013
1CytokinesIBA
02/2013
1Agammaglobulinaemia Tyrosine KinaseIBA
02/2013
1EnzymesIBA
04/2012
1decaneIBA
04/2012
1Antiviral Agents (Antivirals)IBA
08/2007
1AntigensIBA
10/2004
1Proteins (Proteins, Gene)FDA Link
01/2004
1GTP-Binding Proteins (G-Protein)IBA
01/2004
1HIV ProteaseIBA
01/2004
1Viral ProteinsIBA
01/2004
1CMPD 167IBA
11/2003
1Formaldehyde (Formol)FDA Link
06/2003
1ChemokinesIBA
06/2003
1CCR2 ReceptorsIBA
06/2003
1Freund's AdjuvantIBA
06/2003
1mouse Cxcl9 proteinIBA
08/2002

Therapy/Procedure

5Therapeutics
02/2013 - 06/2003
1Oral Administration
08/2013
1Lenses
10/2004